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A near-autonomous AI chemist improves a challenging reaction in medicinal chemistry

Open AI NewsPublished Jun 17, 2026

OpenAI connected its GPT-5.4 model to an autonomous chemistry AI, Maria, to improve the Chan–Lam coupling reaction in medicinal chemistry. The AI system designed and executed experiments, achieving significant yield improvements verified by human chemists.

#autonomous-laboratory #chan-lam-coupling #gpt-5-4 #maria-lab #medicinal-chemistry #openai

A near-autonomous AI chemist improves a challenging reaction in medicinal chemistry

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